Environmental signals and transgenerational epigenetics.

Epigenetics In Transgenerational Responses To Environmental Impacts: Facts And Gaps ebook.ecog-obesity.eu/chapter-biology/epigenetics-in-transgenerational-responses-to-environmental- impacts-facts-and-gaps

Environmentally induced epigenetic transgenerational inheritance of phenotype and disease.

Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is a critical factor in how environment affects biology. Environmental epigenetics provides a molecular mechanism to explain long term effects of environment on the deve...

Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability.

The majority of environmental factors can not modify DNA sequence, but can influence the epigenome. The mitotic stability of the epigenome and ability of environmental epigenetics to influence phenotypic variation and disease, suggests environmental epigenetics will have a critical role in disease etiology and biological areas such as evolutionary biology. The current review presents the molecu...

Lifetime stress experience: transgenerational epigenetics and germ cell programming

The transgenerational epigenetic programming involved in the passage of environmental exposures to stressful periods from one generation to the next has been examined in human populations, and mechanistically in animal models. Epidemiological studies suggest that gestational exposures to environmental factors including stress are strongly associated with an increased risk of neurodevelopmental ...

Epigenetic transgenerational actions of environmental factors in disease etiology.

The ability of environmental factors to promote a phenotype or disease state not only in the individual exposed but also in subsequent progeny for successive generations is termed transgenerational inheritance. The majority of environmental factors such as nutrition or toxicants such as endocrine disruptors do not promote genetic mutations or alterations in DNA sequence. However, these factors ...